CYSTEAMINE 5%
Cyspera Intensive Pigment Corrector is formulated with stabilize cysteamine to address the appearance of discoloration and dark spots.
Cyspera ® Intensive Pigment Corrector Scientis original and innovative formula with stabilized cysteamine to address the appearance of discoloration and dark spots. Its effectiveness and safety have been backed up by numerous clinical studies, renowned dermatologists and skin care professionals worldwide.
80% of melanin synthesis by cysteamine, demonstrated in in vitro studies(10)
67% reduction of dark spot color intensity after 16 weeks of Cyspera® (2)
100% of subjects obtained visible effects after 16 weeks according to investigator(2)
92% of subjects noticed visible effects after 16 weeks(2)
(1) Hsu, C., Mahdi, H. A., Pourahmadi, M., & Ahmadi, S. (2013, April). Cysteamine cream as a new skin depigmenting product. In Journal of the American Academy of Dermatology (Vol. 68, No. 4, pp. AB189-AB189). 360
(2) Mansouri P, Farshi S, Hashemi Z, Kasraee B. (2015). Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double‐blind placebo‐controlled trial. Br J Dermatol, 173(1), 209-217
(3) Farshi S, Mansouri P, Kasraee B. (2018). Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double-blind placebo-controlled study. J Dermatolog Treat, 29(2), 182-189.
(4) Karrabi M, David, J, Sahebkar M. (2020). Clinical evaluation of efficacy, safety and tolerability of cysteamine 5% cream in comparison with modified Kligman’s formula in subjects with epidermal melasma: A randomized, double‐blind clinical trial study. Skin Res Technol.
(5). Kasraee B, Mansouri, P Farshi, S. (2019). Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman's formula. J Cosmet Dermatol, 18(1), 293-295.
(6) Nguyen J, Remyn L, Chung I Y, Honigman A, Gourani‐Tehrani S, Wutami I, Rodrigues M. (2021). Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomized, double‐blinded trial. Australas J Dermatol, 62(1), e41-e46. (7) Karrabi M, Mansournia MA, Sharestanaki E, Abdollahnejad Y, Sahebkar M. (2020). Clinical evaluation of efficacy and tolerability of cysteamine 5% cream in comparison with tranexamic acid mesotherapy in subjects with melasma: a single-blind, randomized clinical trial study. Arch of Dermatol Res, 1-9.
(8) Marini L., Prime Journal, 2019 May/June 70–73
(9) Johnson B. et al. “Novel Combination of a 650-Microsecond Neodymium-doped Yttrium Aluminium Garnet 1,064-nm Laser and Cysteamine Cream for the Treatment of Melasma: A Case Study.” J Clin Aesthet Dermatol. 2020;13(3):28–30
(10) Qui L. et al, J. Invest Dermatol. 2000 Jan;114(1):21-7
Protocol: Short contact application of 15 minutes, once a day, either on the morning or in the evening.
Do not wash the skin before application: Unwashed skin has a natural hydrophilic film which helps prevent any irritation. Apply one pump of Cyspera® to the entire desired area (do not spot treat) and leave on for 15 minutes. If you have sensitive skin or if you are a Cyspera beginner, start with 5 min application for a couple of weeks and gradually increase the duration of application to 15min (without exceeding 15 min). 2. Remove by washing the area with a gentle cleanser. Gently pat the area dry. Apply moisturizer; maintain skin hydration during the day. Apply daily a broad-spectrum sunscreen (SPF 30 or higher) Avoid the use of retinol, AHA or prescription creams. Try our new NEW Cyspera Boost as a replacement of your moisturizer to Increase the luminosity of your skin and enhance the brightening results of Cyspera ®
If you need to remove make-up or have a specific need to wash your skin, wait at least 1 hour before applying Cyspera® and follow the above steps.
Every day, once per day, for 15 minutes.
After 16 weeks of application, Cyspera® is recommended to be used twice a week once per day, for 15 minutes.
Stabilized cysteamine : Potent antioxidant, with demonstrated efficacy in improving the appearance of persistent brown patches and dark spots. Safe and durable skin tone evenness. Safe for long-term use
Niacinamide: Enhancing the skin brightening effectiveness of cysteamine for a more even complexion.
Stabilized Vitamin C: Provides a natural and healthy glow. Helps skin appear more luminous over time
Cyspera Intensive™ Ingredients: Aqua, Paraffinum Liquidum, Cysteamine HCl, Niacinamide, Butyrospermum Parkii (Shea) butter, Glyceryl Stearate, Lecithin, Isopropyl Myristate, Cetyl Alcohol, Ceteareth-20, Ascorbyl Palmitate, Sodium Ascorbyl Phosphate, Octyldodecanol, Phenoxyethanol, Ethylhexylglycerin, Propylheptyl Caprylate, Ceteareth-12, Cetearyl alcohol, Cetyl Palmitate, Parfum (Fragrance), Xanthan Gum, PEG-30 dipolyhydroxystearate, Tocopherol, Beeswax, BHT, Tetrasodium EDTA, Hexyl Cinnamal, Linalool, Geraniol.
Cyspera is the original and innovative skin care product that has gained popularity in recent years due to proven efficacy and visible results against skin discoloration.
Its history can be tracked back to 2010-12, in Geneva Switzerland when Scientis developed a new technology that significantly increases the stability of cysteamine allowing its use in topical products.
Cyspera original formulation has been developed after years of research and is the first cysteamine-based product with clinical results published in peer-reviewed journals(1).
Since 2015, multiple clinical studies have demonstrated its stability and efficacy in inhibiting melanin production in the skin, resulting in a more even skin tone and a more luminous complexion(2-6).
Cysteamine Cream
Cyspera® Intensive Pigment Corrector
(Cysteamine Cream)
(1) Mansouri P, Farshi S, Hashemi Z, Kasraee B. (2015). Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double‐blind placebo‐controlled trial. Br J Dermatol, 173(1), 209-217 (2) Farshi S, Mansouri P, Kasraee B. (2018). Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double-blind placebo-controlled study. J Dermatolog Treat, 29(2), 182-189. (3) Karrabi M, David, J, Sahebkar M. (2020). Clinical evaluation of efficacy, safety and tolerability of cysteamine 5% cream in comparison with modified Kligman’s formula in subjects with epidermal melasma: A randomized, double‐blind clinical trial study. Skin Res Technol. (4). Kasraee B, Mansouri, P Farshi, S. (2019). Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman's formula. J Cosmet Dermatol, 18(1), 293-295. (5) Nguyen J, Remyn L, Chung I Y, Honigman A, Gourani‐Tehrani S, Wutami I, Rodrigues M. (2021). Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomized, double‐blinded trial. Australas J Dermatol, 62(1), e41-e46. (6) Karrabi M, Mansournia MA, Sharestanaki E, Abdollahnejad Y, Sahebkar M. (2020). Clinical evaluation of efficacy and tolerability of cysteamine 5% cream in comparison with tranexamic acid mesotherapy in subjects with melasma: a single-blind, randomized clinical trial study. Arch of Dermatol Res, 1-9.
In clinical studies, results were seen as early as 6 to 8 weeks with daily use. After 16 weeks of usage, significant improvement in the appearance of skin discoloration has been observed.
Intensive phase: Every day, once per day, for 15 minutes.
Maintenance phase: After 16 weeks, Cyspera® is recommended to be used twice a week once per day, for 15 minutes. Cyspera is safe for continued, long-term use. Based on clinical setting observations, improvement continues to be seen after 16 weeks and cysteamine has been prescribed for 6 months of daily use with positive results. Once the desired results are achieved, they can be maintained with twice weekly applications of topical Cyspera. Some of the first Cyspera/Cysteamine patients are still under maintenance regimen.
If your skin is sensitive, begin with twice-a-week 5 min application. Gradually increase frequency to every other day, and then advance to daily use or as tolerated.
Cysteamine is not a photosensitizer. Topical Cyspera Intensive™ can be applied regardless of the sun intensity, on any skin phototypes. In any case, the use of a high SPF sunscreen cream is recommended.
What happened if I leave the cream for more than 15 min?
“This cream has given me so much hope that I can’t even begin to describe it. Not only does it work, it also has zero side effects. I can’t wait to go through the 16 weeks of application to see the impact. Thank you!!”
“Best product for hyperpigmentation! I've used everything made for hyperpigmentation for the last 2 years and this is the only product that has helped my dark pigment. I've used it for about 4 months total, and I would say my pigmentation is nearly gone”
“Was on hydroquinone on and off for several years and although I managed to lighten my dark patches, as soon as I stopped, the dark patches returned. Stabilized Cysteamine 5% Cream is a game changer. I have used it for 4 weeks and I can tell that there is 30% improvement to my dark patches”
“ Finally, something that works, Stabilized Cysteamine 5% Cream is actually working on my dark patches. You have to be patient and keep going”
- Minaz S, USA
- Mika V, USA
- Hilary, USA
- Amber D, USA
Users noticed significant improvement in the appearance of discoloration.c
Pigment correction in the appearance of stubborn discoloration.
PIGMENT CORRECTION
Cyspera Intensive™
formulated with a Cysteamine Isobionic-Amide Complex™ that delivers a powerful antioxidant activity to improve the appearance of persistent brown patches and dark spots.
