Cyspera Intensive System ™

299.00 USD
Tax excluded


Cyspera Intensive System ™ : a 3-step daily routine, based on novel depigmenting ingredients (isobionic-amide and cysteamine), that corrects all types of undesired pigmentation, including the most stubborn brown patches and dark spots. Visible improvements in the first 2 weeks of use, optimal and more remarkable results after 16 weeks. Suitable for all skin types. Clinically proven to significantly improve the skin tone for a brighter, more radiant and even complexion.

Each System contains :
Cyspera Intensive™ (30 ml / 1 FL.OZ)
Cyspera Neutralize™ (50 ml / 1.75 FL.OZ)
Cyspera Boost™ (30 ml / 1 FL.OZ)

  • Patent-pending Cysteamine-Isobionic amide Complex: a revolutionary synergistic combination that targets, corrects and prevents all types of pigmentation, including the most stubborn brown patches and dark spots.
  • Clinically proven to improve the appearance of all forms of undesired discoloration, for a brighter, more even-looking skin
  • Noticeable results as early as 2 weeks and remarkable improvement after 16 weeks
  • Helps skin appear visibly smoother and more luminous over time
  • Helps to fade the size and intensity of dark spots and to limit the appearance of new spots
  • Sooth skin and support skin barrier function.
  • Effective on all skin types and tested on skin of multiple ethnicities
  • Hydroquinone-free and safe for continued, long-term use
  • Non-phototoxic, well tolerated and safe to use during the summer
  • Free from animal-derived ingredients, cruelty-free & not tested on animals.

Protocol: Short contact application of 5 to 15 minutes, once a day, either in the morning or in the evening

Do not wash the skin before application: Unwashed skin has a natural hydrolipidic film which helps prevent irritation.

1. Apply 1 pump, a thin layer of Cyspera Intensive™ and leave on for 15 minutes. The cream must be applied on full face not just the affected area.

          If you have sensitive skin or if you are a cysteamine beginner, start with 5 min application for a couple of weeks and gradually increase the duration of application to 15min (without exceeding 15 min).


2. Apply 2 pumps of Cyspera Neutralize™ directly to the skin and rinse off with water


3. Complete your routine with 1 to 2 pumps of Cyspera Boost™ to increase the luminosity of your skin and enhance the brightening results of Cyspera Intensive™

4. Use high SPF sunscreen
Maintain your skin hydrated during the day.

If the evening, after gentle cleansing, use Cyspera Boost™ (avoid the use of retinol, AHA or prescription cream)

For users who have make-up on their skin or who desire to cleanse their skin prior to applying Step 1 Intensive, cleanse skin, wait at least 1 hour before applying Cyspera Intensive™ and follow up the above steps (1 to 3).

In the next morning, use a high SPF sunscreen

Every day, once per day, for maximum 15 minutes.

After 16  weeks of application, Cyspera Intensive Systemis recommended to be used twice a week once per day, for 15 minutes. The use of Cyspera Boost™ can be continued in the maintenance phase, once or twice daily

Click here to download the protocol


Depigmenting effects

  • Equivalent skin tone lightening compared to gold standard during all the duration of the application
  • Equivalent skin tone lightening compared to gold standard during all the duration of the application 100 % of subjects showed an improvement in hyperpigmentation already after 4 weeks [1]
  • 70 % of subjects were very satisfied with the product after 16 weeks [1]
  • 40% reduction of dark spots surface and color intensity (mMASI score), after 16 weeks [1]
  • Subjects’ quality of life significatively improved versus gold standard, after 8 and 16 weeks of use

Skin health benefits

  • 100 % of subjects showed improvements in skin hydration, skin texture, (measured by Visia) after 16weeks
  • 92% of subjects showed an improvement in skin smoothing after 16 weeks[1]
  • 100% of subjects agreed that their tone was more even, more radiant and with less wrinkles after 16 weeks. [1]

[1] Independent study conducted by M. Sachdev and al. on 80 melasma patients divided in 3groups : Cyspera Intensive System™, Placebo, Tri-Luma®

Potent antioxidant, with demonstrated efficacy in improving the appearance of persistent brown patches and dark spots. Safe and durable skin tone evenness. Safe for long-term use

Scientis’ new proprietary patent-pending ingredient, that delivers a synergistic effect enhancing the skin brightening effectiveness of cysteamine for an even, more radiant complexion.

Helps to gently exfoliate to gradually sweep away dull skin flakes and reveal smoother and brighter skin. (Used at a specially designed low level )

Provides a natural and healthy glow. Helps skin appear more luminous over time

Helps accelerate the skin renewal which, thanks to Cysteamine-Isobionic amide complex, will be less pigmented, for smoother, more even, and younger-looking skin

Additional skin health supporting ingredients, such as moisturizing sugars, pro-vitamin B5 and nourrishing lipids (squalane, shea butter) to sooth the skin and helps prevent redness that often leads to pigmentation look

Cyspera Intensive ™ 

Ingredients: Aqua, Cysteamine HCl, Paraffinum Liquidum, Glycolic Acid, Cetyl Alcohol, Isobionic-amide, Glycerin, Glyceryl Stearate, Isopropyl Myristate, Lecithin, Sodium Ascorbyl Phosphate, Butyrospermum Parkii (Shea) butter, Ceteareth-20, Ascorbyl Palmitate, Phenoxyethanol, Glycine Soja (Soybean) Oil, Parfum (Fragrance), Ethylhexylglycerin, Propylheptyl Caprylate, Ceteareth-12, Cetearyl Alcohol, Cetyl Palmitate, Octyldodecanol, Xanthan Gum, PEG-30 dipolyhydroxystearate, Tocopherol, Retinol, Tetrasodium EDTA, Glycine Soja Oil Unsaponifiables, Helianthus Annus, Seed Oil Unsaponifiables.

Cyspera Neutralize ™ 

Ingredients: Aqua, Glycerin, Lactic Acid, Decyl Glucoside, Pentylene Glycol, Cocamidopropyl Betaine, Sodium Hydroxide, Arginine, Maltooligosyl Glucoside, Hydrogenated Starch Hydrolysate, Lactobionic Acid, Parfum (Fragrance), Hydroxyethylcellulose, Potassium Sorbate, Alpha-Glucan Oligosaccharide, Polymnia Sonchifolia Root Juice, Maltodextrin, Centella Asiatica Leaf Extract, Linum Alpinum Flower/Leaf/Stem Extract, Disodium Phosphate, Sodium Phosphate, Lactobacillus, Polysorbate 60, Citric Acid.

Cyspera Boost ™ 

Ingredients: Aqua, Glycerin, Octyl dodecanol, Cetyl Alcohol, Panthenol, Butyrospermum Parkii (Shea) butter, Hordeum Vulgare Seed Flour, Potassium Cetyl Phosphate, Propylheptyl Caprylate, Behenyl Alcohol, Squalane, XylitylgIucoside, Paraffinum Liquidum, Ascorbyl Palmitate, Sodium Ascorbyl Phosphate, Phenoxyethanol, Glycine Soja (Soybean) Oil, Ethylhexyl glycerin, Anhydroxylitol, Tetrasodium Glutamate Diacetate, Tocopherol, Xanthan Gum, Xylitol, Retinol, Glycine Soja Oil Unsaponifiables, Helianthus Annus Seed Oil Unsaponifiables, Tasmannia Lanceolata Fruit/Leaf Extract

Scientis, the pigmentation authority, is a pioneer in the development of new technologies allowing the use of cysteamine in topical products by significantly increasing its stability. This scientific breakthrough is the result of more than 10 years of research conducted by our in-house experts in Switzerland on the formulation of cysteamine now combined with Isobionic-amide : this new molecule has a synergistic effect that enhances the skin brightening effectiveness of cysteamine and Improves radiance and skin tone.

Unique patent- pending Cysteamine-Isobionic Amide Complex acting on two levels: it prevents the overproduction of melanin and helps to inhibit the transfer of melanin to the surface of the skin, thus reducing the amount of melanin pigment in the skin and its visibility.

Cysteamine (Cyspera Intensive™) : Potent antioxidant with proven efficacy in correcting skin pigmentation; helps to inhibit the overproduction of melanin by regulating the activity of tyrosinase and peroxidase enzymes.

Isobionic-amide (Cyspera Intensive™, Cyspera Boost ™) : a derivative of Vitamin B3 that helps to reduce the transfer of melanin into the skin’s surface layer and that synergistically enhances the brightening efficacy of cysteamine.

AHA such as Glycolic acid (Cyspera Intensive ™) and Lactic acid (Cyspera Neutralize™) are gentle exfoliating ingredients that helps to sweep away the melanin-rich surface layers of the skin and help accelerate the renewal process of the skin, which, thanks to cysteamine and isobionic-amide, will tend to be less pigmented after regular use.

Cyspera Intensive System™ also contains stabilized forms of Vitamin C, retinol and other moisturizing and nourishing ingredients. Thus, it provides a complete set of actions, such as brightening, evening out skin tone, antioxidant, smoothing to soothing and maintaining good skin barrier function. This is essential for hyperpigmentation-prone skin in order to minimize the recurrence of surface pigmentation and protect the skin against future damages.


Cyspera Intensive Systemcan last up to 8 weeks.

The system is constituted of 3 products with the 1st one containing cysteamine and the 3rd one containing isobionic amide.

Intensive phase: Every day, once per day, for 15 minutes.

Maintenance phase: After 16 weeks, Cyspera Intensive System ™ is recommended to be used twice a week once per day, for 15 minutes. 

Cyspera is safe for continued, long-term use. Based on clinical setting observations, improvement continues to be seen after 16 weeks and cysteamine has been prescribed for 6 months of daily use with positive results. Once the desired results are achieved, they can be maintained with twice weekly applications of topical Cyspera. Some of the first Cyspera/Cysteamine patients are still under maintenance regimen.

If your skin is sensitive, begin with twice-a-week 5 min application. Gradually increase frequency to every other day, and then advance to daily use or as tolerated.   

If signs of irritation, discontinue use until skin irritation subsides

Cysteamine is not a photosensitizer. Topical Cyspera Intensive™ can be applied regardless of the sun intensity, on any skin phototypes. In any case, the use of a high SPF sunscreen cream is recommended.

A longer exposure to the cream will not give you quicker results. Cyspera best performance is expected when it's used regularly every day (15 min) with consistent application for up to 2 to 4 months.



“This cream has given me so much hope that I can’t even begin to describe it. Not only does it work, it also has zero side effects. I can’t wait to go through the 16 weeks of application to see the impact. Thank you!!”


“Best product for hyperpigmentation! I've used everything made for hyperpigmentation for the last 2 years and this is the only product that has helped my dark pigment. I've used it for about 4 months total, and I would say my pigmentation is nearly gone”


“Was on hydroquinone on and off for several years and although I managed to lighten my dark patches, as soon as I stopped, the dark patches returned. Stabilized Cysteamine 5% Cream is a game changer. I have used it for 4 weeks and I can tell that there is 30% improvement to my dark patches”


“ Finally, something that works, Stabilized Cysteamine 5% Cream is actually working on my dark patches. You have to be patient and keep going”

- Minaz S, USA

- Mika V, USA

- Hilary, USA

- Amber D, USA



Users noticed significant improvement in the appearance of discoloration.c


Pigment correction in the appearance of stubborn discoloration.

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